Multi-objective optimal split-plot experiments for the pharmaceutical industry

Kalliopi Mylona, King’s College London, UK


13 December 2023 (Wednesday) – 16:00


In this talk, I will give two examples of how the multi-objective optimal design methodology can be used in pharmaceutical experiments. The aim of the experimentation was to explore the response surface with respect to various experimental factors, with two randomisation levels, as well as to provide good quality predictions in the experimental region. The applications include pure-error based optimality criteria, corresponding to the fitted model inference and prediction quality. I will mainly talk about the design decision that was made for the two experiments.

The talk is based on two joined works with M. Otava and O. Egorova, A. Olszewska, B. Forbes.

Seminário no âmbito do Mestrado em Bioestatística