SEMINÁRIO ÂMBITO Projecto PERSSILAA: Biological Clocks, Ageing, and Longevity


  • Prof. Riccardo Marioni – School of Molecular – Centre for Genomic and Experimental Medicine – University of Edinburg
  • FUNDAÇÃO FCUL – FCUL – Campo Grande – Bloco C1 Piso 3 – ANFITEATRO – 9:30h
  • Sexta-feira, 4 de Março de 2016

Biological clocks that correlate highly with chronological age may provide insight into the impact of lifestyle on rate of ageing, and improve the prediction of adverse health outcomes. Here, I will discuss biological clocks based on several measures including telomere length, glycans, transcriptomics, and epigenetics. The main focus of the presentation will be on the ‘epigenetic clock’, which utilises DNA methylation to predict chronological age. I will present an overview of the epigenetic clock, its derivation, and its associations with outcomes such as mortality, cognitive ability, and physical health. I will also discuss its relationship with other biological clocks, such as telomere length. The primary data sources for these analyses are two Scottish studies of ageing: the Lothian Birth Cohorts of 1921 (LBC1921, n~550) and 1936 (LBC1936, n~1,000). Both cohorts have concurrent DNA methylation and telomere measurements at three time points (ages 70, 73, and 76 in LBC1936 and ages 79, 87, and 90 in LBC1921).